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KMID : 0363220090470091054
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Korean Journal of Dermatology
2009 Volume.47 No. 9 p.1054 ~ p.1059
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Park Young-Do
Kim Sung-Ae
Cho Jae-We
Lee Kyu-Suk
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Abstract
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Carcinoid syndrome exhibits a constellation of symptoms typically exhibited by patients with carcinoid tumors that produce neuroendocrine mediators, including serotonin. Carcinoid syndrome is diagnosed by increasing urinary 5-hydroxyindoleacetic acid and manifestations of gastrointestinal tract, respiratory, cardiovascular, and skin involvement, which occurs in ＜10% of patients. Cutaneous manifestations are flushing, telangiectasias, pellagra dermatitis, and scleroderma-like lesions, which are relatively rare. A 60-year-old woman presented with sclerotic skin lesions on both legs. On examination, a 10×10 cm solid mass was palpable on the right lower abdomen, and she had facial flushing and telangiectasia, but Raynaud’s phenomenon was absent. The urinary 5-hydroxyindoleacetic acid was elevated (68.2 mg/day). Abdominal and pelvic CT scans showed a right ovarian tumor which was diagnosed as a carcinoid tumor by CT-guided needle biopsy. Thus, we report, for the first time, a case of carcinoid syndrome with scleroderma- like lesions in a Korean patient. If facial flushing and a scleroderma-like lesion present together, one should consider a carcinoid tumor.
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KEYWORD
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Carcinoid syndrome, Scleroderma, Serotonin
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